Muscle and Exercise Physiology

Research Interest

Our research group interested in skeletal muscle which is the major tissue in the body. Skeletal muscle has highly plasticity in responses to numerous conditions, i.e., spontaneous regeneration after injury, hypertrophy after resistance training, and atrophy after disuse/aging. Hence, understanding skeletal muscle physiology is the enormous field of research. In addition to skeletal muscle research, the application of exercise training regimen to improve sport performance/skeletal muscle in both human and horse are also interested.            

Muscle Physiology Research

The current area of skeletal muscle physiology research covers the wide range of investigations from cell culture and animal models. Cell culture condition that mimics skeletal muscle cell growth, i.e., proliferation and differentiation in responses to growth factors, hormones, and myokines are the main investigations. Additionally, skeletal muscle plasticity research in rodent models, i.e., regeneration, hypertrophy, and atrophy are conducted to explore the underlying mechanisms of skeletal muscle adaptation and the contribution of skeletal muscle stem cell in these plasticity processes.            

Exercise Physiology Research

The effects of exercise training regimen on skeletal muscle fiber type transition and intramuscular metabolic adaptation that impact exercise performance in Polo pony are the primary research focus. Moreover, the associations of physiological responses obtained from field and laboratory tests on exercise performance of professional futsal player are investigated.            

Members

Asst. Prof. Dr. Ratchakrit Srikuea

ผศ.ดร. รัชกฤต ศรีเกื้อ

(Principal Investigator)

Dr. Stephen M.K. Chan

Dr. Stephen M.K. Chan

Students

  • Therdtham Chawrai (Graduated)
  • Kanokwan Suhatcho

Research Collaboration

- National

1. Asst. Prof. Dr. Muthita Hirunsai (Srinakharinwirot University)

2. Dr. Metha Chanda (Kasetsart University)

3. Dr. Niromlee Makaje (Kasetsart University)

4. Assoc. Prof. Dr. Boon-ek Yingyongnarongkul (Ramkhamhaeng University)

Publications

  • 1 ) Hirunsai M* and Srikuea R. Differential effects of heat stress on fiber capillarization in tenotomized soleus and plantaris muscles. Int J Hyperthermia. 2018;34(4):432-41. (IF 3.440)
  • 2 ) Srikuea R* and Hirunsai M. Effects of intramuscular administration of 1α,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis. J Appl Physiol. 2016;120(12):1381-93. (IF 3.256)
  • 3 ) Chanda M, Srikuea R, Piyachaturawat P*. Semi-automated microbiopsy device: a potential tool for muscle sampling in horse. Thai J Vet Med. 2016;46(4):569-77. (IF 0.274)
  • 4 ) Hirunsai M, Srikuea R, Yimlamai T*. Heat stress promotes extracellular matrix remodelling via TGF-β1 and MMP-2/TIMP-2 modulation in tenotomised soleus and plantaris muscles. Int J Hyperthermia. 2015;31(4):336-48. (IF 3.440)
  • 5 ) Schroder EA, Harfmann BD, Zhang X, Srikuea R, England JH, Hodge BA, et al. Intrinsic muscle clock is necessary for musculoskeletal health. J Physiol. 2015;593(24):5387-404. (IF 4.540)